Even for most of us who spend our time working in the field of experimental diabetes, the primary concern is the disorder which occurs in the human subject. To stimulate our thoughts in this field, I will attempt, briefly, to list the possible causes of this disorder.

Some Possible Causes of Diabetes

1. Defects in the pancreas as a whole, including the beta cells. 2. Defects in the formation of insulin. 3. Defects in the liberation of insulin. 4. Abnormal destruction of insulin. 5. Genetic defects involving insulin-dependent reactions. 6. Excess of diabetogenic agents. 7. Genetic defects making tissues abnormally suspectible to diabetogenic substances. 8. Genetic defects independent of hormonal actions.